His longest work, the three-volume Uzumaki, is about a town's obsession with spirals: people become variously fascinated with, terrified of, and consumed by the countless occurrences of the spiral in nature.

Ito's universe is also very cruel and capricious his characters often find themselves victims of malevolent unnatural circumstances for no discernible reason or punished out of proportion for minor infractions against an unknown and incomprehensible natural order. For example: A girl's hair rebels against being cut off and runs off with her head Girls deliberately catch a disease that makes them beautiful but then murder each other a woman treats her skin with lotion so she can take it off and look at her muscles, but the skin dissolves and she tries to steal her sister's skin, etc. The most common obsessions are with beauty, long hair, and beautiful girls, especially in his Tomie and Flesh-Colored Horror comic collections. Nevertheless, upon graduation he trained as a dental technician, and until the early 1990s he juggled his dental career with his increasingly successful hobby - even after being selected as the winner of the prestigious Umezu prize for horror manga.

Born in Gifu Prefecture in 1963, he was inspired from a young age by his older sister's drawing and Kazuo Umezu's comics and thus took an interest in drawing horror comics himself.

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